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When mixed together, CNS depressants amplify each other's effects, which can cause severely reduced heart rate and even death. Overdoses of depressants produce effects that are the same as alcohol overdoses. The person becomes extremely drowsy and passes out. Their heartbeat slows and respiration will become shallow. Their skin may feel cold and clammy, and death may result from respiratory failure.

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" Drug Intell Clin Pharm 22 (1988): 296-9 Kikta DG, Devereaux MW, Chandar K "Intracranial hemorrhages due to phenylpropanolamine. " Stroke 16 (1985): 510-2 Lake CR, Zaloga G, Clymer R, Quirk RM, Chernow B "A double dose of phenylpropanolamine causes transient hypertension. " Am J Med 85 (1988): 339-43 Edwards M, Russo L, Harwood-Nuss A "Cerebral infarction with a single oral dose of phenylpropanolamine.

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